사람에서 이종골과 조직 접합제의 혼용후 골형성 효과에 관한 연구
Effects of fibrin glue on bone formation in combination with deproteinized bone xenografts in humans
김문수, 김수관, 임성철, 김학균, 문성용,
소속 상세정보
김문수 ( Kim Moon-Soo ) - 조선대학교 치과대학 구강악안면외과학교실
김수관 ( Kim Su-Gwan ) - 조선대학교 치과대학 구강악안면외과학교실
임성철 ( Lim Sung-Chul ) - 조선대학교 의과대학 병리학교실
김학균 ( Kim Hak-Kyun ) - 조선대학교 치과대학 구강악안면외과학교실
문성용 ( Moon Seong-Yong ) - 조선대학교 치과대학 구강악안면외과학교실
KMID : 0355620080340010019
Abstract
Thirty-six sinus grafts were performed in 34 patients with an alveolar crest bone height in the posterior maxilla of 3 to 5 mm before grafting. The sinuses were grafted using Bio-Oss alone or mixed with fibrin glue. Group 1 was the control group and included 25 patients who received a xenograft mixed in saline. Group 2 comprised 9 patients who received a xenograft and fibrin glue. The study was further subdivided at the time of 9 months. This histologic study evaluated by hematoxylin-eosin (H&E) and histomorphometric analysis whether fibrin glue in combination with Bio-Oss enhances bone regeneration in sinus floor elevation in humans. The new bone formation was better in Group 2 than in Group 1, but the difference was not significant. The absorption of the graft material was faster in Group 2 than in Group 1, in the short term, but better in Group 1 over the long term, although the difference was not significant. Lamellar bone was formed earlier in Group 1 compared to Group 2, but the difference was not significant. Overall, the surgery site stabilized earlier with new bone formation in Group 2 than in Group 1, but the difference was not significant. Combining a fibrin sealant and Bio-Oss could lead to improved scaffolds for bone tissue engineering based on the synergistic effects of the biomaterials. Therefore, Bio-Oss or Bio-Oss plus Tisseel may be used depending on the situation.
키워드
Fibrin glue;Bone formation;Deproteinized bone xenografts
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